Gif Central boasts hundreds of funny animated gifs. Only the best of the best make it onto this site, with most of them having an accompanying source. No tumblr-esque one-second-long disappointments. No obscure titles or descriptions.
This is an animated gif of San Jose, California actor Josh Holloway taking his glasses off in surprise. Pretty sure this is from the TV show Lost, in which Holloway player the character James "Sawyer" Ford.